Parker was romantically involved with actor Robert Downey, Jr. from 1984 until 1991. They met on the set of Firstborn. Downey had a drug problem, which affected their relationship. Parker has said, "I believed I was the person holding him together."

On May 19, 1997, she married actor Matthew Broderick, to whom she was introduced by one of her brothers at the Naked Angels theater company, where they both performed. The couple married in a civil ceremony in a historic synagogue on the Lower East Side in Manhattan. The couple's son, James Wilkie Broderick, was born on October 28, 2002. He was named after Broderick's father, the actor James Joseph Broderick, and writer Wilkie Collins.

Parker and Broderick's surrogate mother delivered their twin daughters, Marion Loretta Elwell and Tabitha Hodge, on June 22, 2009. Their middle names of "Elwell" and "Hodge" are from Parker's mother's family.

As of 2009, she lives in New York City with her husband, son, and daughters. They also spend considerable time at their second home near Kilcar, a village in County Donegal, Ireland, where Broderick spent summers as a child.

Parker is a prominent member of the Hollywood's Women's Political Committee. She is UNICEF's Representative for the Performing Arts; in 2006, she traveled to Liberia as a UNICEF celebrity ambassador. She said, "It's a place that gets little or no attention, so we're going to try and bring some attention to it". She is a UNICEF Goodwill Ambassador for the United States.

Actually, I agree with the other chap. What an untalented slut bitch.

i cant bear reading any more of her slutty endevours

I hope Broderick's practised driving on the left, is all.