headache volcano...
I once woke up in bed at about midnight with the most stonking headache anyone could imagine..

i whacked my boyfriend awake and ordered him to go and get me some asprin, paracetamol, ectasy - anything he could find in the bathroom cabinet.

He came back up with a pint of water and the only drug he could find downstairs was a packet of dispersible asprin (those large thick 50p sized tablets that you dissolve in a pint of water then guzzle down)

I absolutely HATE the taste of tablets/ medicines, and these were hideous NHS issued one not ones with a flavour or anything that you find in boots.. i was not going to drink that fucking poison even if i was dying.

So... what i decided was that i would break the two large asprins into four peices each, and just take them as 8 normal sized tablets.. genius.

swig of water, little bit of asprin, swallow.. gulp of water, bit of asprin, swallow... glug of water, bit of asprin, swallow.. swig of water QUEUE FUCKING VOLCANOE STYLE EXPLOSION OF FIZZY WHITE MESS SPILLING OUT MY NOSE, MOUTH, AND FUCKING ANY ORIFICE IT COULD FIND ITS WAY OUT OF ALL OVER THE BED SHEETS FOLLOWED BY VOMIT.

turns out its best to just stick to the instructions. you need at least 20 pints of water to dissolve those fuckers. oops.
(nettestar meeow, Sat 18 Sep 2010, 17:45, 10 replies)

And I bet they made you think your tits were radishes too.

( Amorous Badger NAKED BEA ARTHUR PHOTOS 4U, Sat 18 Sep 2010, 17:46, closed)

i like tits

( broadsword w⚓, Sat 18 Sep 2010, 19:01, closed)

Doofus, she said goodnaturedly
What did you think they were going to do?
(TDub Nunc id vides, nunc ne vides on, Sat 18 Sep 2010, 19:57, closed)

If you got it on video...
I'd pay to watch.
(Vinnie Strokes Got bummed on, Sat 18 Sep 2010, 22:53, closed)

Hate the taste of soluble medicines?
Have you tried dissolving them in fruit juice (NOT grapefruit)?
(The Incredible Sulk Finally remembered his password on, Sun 19 Sep 2010, 3:43, closed)

Why NOT grapefruit?
Apart from the fact that that shit is nasty?
(Falstaff's Spiritual Successor, Sun 19 Sep 2010, 9:20, closed)

Swiped wholesale from bluelight.ru with thanks to the original poster PHD
Grapefruit Juice FAQ

Grapefruit juice can act as a potentiator for the following prescription drugs sometimes used recreationally:

* codeine
* methadone
* oxycodone (OxyContin, Percoset)
* dextromethorphan (DXM)
* alprazolam (Xanax)
* clonazepam (Klonopin, Rivotril)
* midazolam (Versed)
* triazolam (Halcion)

Caution should be excercised if consuming grapefruit juice before or while taking these drugs. Though most people report mild potentiation (if any), if one is taking extremely large doses, any potentiation could be dangerous.

Method of Action
Grapefruit juice can inhibit the gastrointestinal activity of two enzymes known as cytochrome P450 CYP3A4 and CYP1A2, though the effect on CYP1A2 is minimal. This causes elevated plasma levels of some drugs, because they are able to pass into the bloodstream without being broken down by enzymes in the intestine. Due to variations in enzyme levels in the intestine from person to person, effects will vary.

The specific chemical responsible for this action is not known. There are a few suspects including various flavonoids and other phytochemicals called furanocoumarins. Concentrations of these compounds vary from one batch of juice to another. Higher concentrations are found in white juice compared to red, and the highest concentrations are found in the pulp of the fresh fruit. One glass (200 ml) of fresh juice was found to be equal in effect to two or three glasses of double strength reconstituted frozen juice. This suggests that store bought juice, which is often from concentrate, must be consumed in large quantites to for effects to be noticed. Consuption of 6-8 glasses of fresh juice may lead to inhibition of CYP3A4 in the liver. The potentiating effect of grapefuit juice may last 5 or mores hours after ingestion.

A Note on Codeine & Oxycodone
Codeine is metabolised by both CYP3A4 and CYP2D6. CYP3A4 metabolised codine into norcodine which isn't very active, while CYP2D6 metabolises codiene into morphine which is responsible for codiene's effect. When the CYP3A4 enzyme is inhibited by grapefruit juice, more codiene may be metabolised by CYP2D6. This is theoretical and is not supported by literature at this time.

Like codeine, oxycodone is metabolized by both CYP3A4 and CYP2D6, with the more potent metabolite, oxymorphone, produced by CYP2D6. When the CYP3A4 pathway is blocked, more oxycodone may be metabolised by CYP2D6.

Grapefruit Juice and Cimetidine (Tagamet)
Cimetidine acts on a different enzyme than grapefruit juice, specifically CYP2D6. CYP2D6 metabolises many opiates and opiods, but grapefruit juice has no effect on CYP2D6.

Sources:
www.postgradmed.com/issues/19...99/cadieux.htm
www.powernetdesign.com/grapef...0abstract.html
www.mayo.edu/proceedings/2000/sep/7509r1.pdf
www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
www.tthhivclinic.com/pdf/Recdrug2.pdf
(unclestinky, Sun 19 Sep 2010, 14:55, closed)

so not really an issue
with aspirin
(unclestinky, Sun 19 Sep 2010, 14:57, closed)

well, possibly not an issue for aspirin
but Good Post, unclestinky. I'll try to add a little:

I just think it keeps things simpler to overall not use Grapefruit; rather than trying to research and remember what it's safe with and what it isn't safe with. After all; I was giving general advice, for all soluble medicines.

For example, Co-codamol is a common analgesic (painkiller), available in soluble formulations and "over the counter"; and contains Codiene which is affected. (Although depending on your point of view, I realise you might actually want to slow down your metabolism. As I understand it, it could potentially enhance the effectiveness of low-dose codiene; without overloading you with paracetamol by exceeding the maximum dosage.)

However, each drug will be affected in a different way. While, for most, keeping a single dose in your system a bit longer might not be a concern; if said drug has a low therapeutic index, or you're taking multiple doses over time, then you risk overdoses. Keep in mind that the above list is not exhaustive, it is concerned with drugs than can be used recreationally. So if aspirin was affected, it wouldn't show up on that list.

More information here: en.wikipedia.org/wiki/List_of_drugs_affected_by_grapefruit

And as Falstaff's Spiritual Successor picked up on: If nothing else, it has a more bitter and less sweet taste than the alternatives; which means it's not as good at masking foul tastes.

(I'm not a medical professional. Use medicines with care. Always read the label.)
(The Incredible Sulk Finally remembered his password on, Mon 20 Sep 2010, 2:40, closed)

You had me at
Fizzy white mess
(lemonadegame, Mon 20 Sep 2010, 0:19, closed)