well, possibly not an issue for aspirin
but Good Post, unclestinky. I'll try to add a little:

I just think it keeps things simpler to overall not use Grapefruit; rather than trying to research and remember what it's safe with and what it isn't safe with. After all; I was giving general advice, for all soluble medicines.

For example, Co-codamol is a common analgesic (painkiller), available in soluble formulations and "over the counter"; and contains Codiene which is affected. (Although depending on your point of view, I realise you might actually want to slow down your metabolism. As I understand it, it could potentially enhance the effectiveness of low-dose codiene; without overloading you with paracetamol by exceeding the maximum dosage.)

However, each drug will be affected in a different way. While, for most, keeping a single dose in your system a bit longer might not be a concern; if said drug has a low therapeutic index, or you're taking multiple doses over time, then you risk overdoses. Keep in mind that the above list is not exhaustive, it is concerned with drugs than can be used recreationally. So if aspirin was affected, it wouldn't show up on that list.

More information here: en.wikipedia.org/wiki/List_of_drugs_affected_by_grapefruit

And as Falstaff's Spiritual Successor picked up on: If nothing else, it has a more bitter and less sweet taste than the alternatives; which means it's not as good at masking foul tastes.

(I'm not a medical professional. Use medicines with care. Always read the label.)
(The Incredible Sulk Finally remembered his password on, Mon 20 Sep 2010, 2:40, Reply)