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# A 20-YEAR-OLD WOMAN REPORTED ABOUT GIGGLE INCONTINENCE DESPITE ANTIMUSCARINIC THERAPY. THEREFORE WE INJECTED BOTULINUM TOXIN A INTO THE DETRUSOR MUSCLE. THE EFFECT OF BOTULINUM TOXIN A APPEARED ABOUT 1 WEEK AFTER INJECTION AND NO MORE LEAKAGE WAS OBSERVED
EVEN DURING VIGOROUS LAUGHTER. A CONTROL UROFLOWMETRY SHOWED A GOOD VOIDING RATE WITHOUT ANY RESIDUAL VOLUME. BOTULINUM TOXIN A MIGHT BE AN ALTERNATIVE FOR PATIENTS WITH GIGGLE INCONTINENCE AFTER UNSUCCESSFUL ANTIMUSCARINIC TREATMENT.

[Botulinum toxin A injection for treatment-refractory giggle incontinence.]
Wefer B, Seif C, van der Horst C, Junemann KP, Braun PM. Urologe A. 2007 Apr 26; [Epub ahead of print] German.
(, Fri 27 Apr 2007, 14:16, archived)