Synephrine alkaloids increase energy expenditure and decrease food intake through activation of alpha- and beta-adrenergic receptors.Synephrine alkaloids may also decrease food intake by reducing gastric motility.
(
gronkpan @vomitinglarry.bsky.social,
Sat 4 Oct 2008, 2:38,
archived)
Several studies have demonstrated that synephrine alkaloids reduce food intake and white fat cells in rats, hamsters, and dogs.Synephrine also promotes lipolysis in adipocytes through beta-adrenergic stimulation.
( gronkpan @vomitinglarry.bsky.social,
Sat 4 Oct 2008, 2:39,
archived)
A 28-year-old man suffered a massive myocardial infarction after abusing synephrine tablets (dose not provided).An overdose of synthetic synephrine in children caused nausea, vomiting, irritation, tachycardia, and a rapid increase in blood pressure.
( gronkpan @vomitinglarry.bsky.social,
Sat 4 Oct 2008, 2:42,
archived)
Hmm.In a 6-week, double-blind, placebo-controlled, randomized study, 23 subjects with body-mass indices more than 25 kg/m 2 were assigned to 1 of 3 groups. Group A received a mixture containing C. aurantium 975 mg (6% synephrine alkaloid), St. John's wort 900 mg (3% hypericin), and caffeine 528 mg; group B received a maltodextrin placebo; and group C was a control without placebo.
(,
Sat 4 Oct 2008, 2:41,
archived)
Because of the potential for additive effects, synephrine use should be avoided in patients with hypertension, tachyarrhythmia, or narrow-angle glaucoma.Ephedrine and synephrine are banned by many sports agencies. A single dose of a commercially available synephrine product did not cause a false-positive response in an amphetamine assay.
( gronkpan @vomitinglarry.bsky.social,
Sat 4 Oct 2008, 2:42,
archived)
