Edit: Not the first shuttle launch.
The first one going to the ISS.
(, Mon 12 Feb 2024, 23:57, Reply)
The first orbital shuttle launch was the logically-named STS-1 in 1981.
The confusingly-named STS-88 was the 93rd orbital launch of a space shuttle. It occurred in 1998 (12 years after the Challenger disaster, 5 years before the Columbia disaster), and was the first Shuttle mission to take part in constructing the ISS.
(, Tue 13 Feb 2024, 19:49, Reply)