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# ris?
Am i being thick? Dont get it.
(I helped save b3ta! Kung_Fu_Russ ran out of amusing signatures on, Tue 29 Sep 2009, 18:53, archived)
# Yes
Check the file name, thicky.
(I helped save b3ta! 2 Can Chunder Word to your mums, I came to prod bums, Tue 29 Sep 2009, 18:55, archived)
# oh...ok.,....
i dont think i was being THAT thick....
(I helped save b3ta! Kung_Fu_Russ ran out of amusing signatures on, Tue 29 Sep 2009, 19:10, archived)
# To recover
You could comment how Thalidomide was in fact a very effective drug but sadly released as a mixed isomer form when in fact it was only one isomer that was harmful (I believe R was safe and the S isomer harmful causing birth defects) thus heightening the tragedy of it all.
(I helped save b3ta! Marty McFly can't grate cheese without getting angry, Tue 29 Sep 2009, 19:27, archived)
# SCIENCE!
*suitably impressed*
(I helped save b3ta! Crystal Magnet Like a diamond geezer, but better, Tue 29 Sep 2009, 19:34, archived)
# apparently, the "safe" isomer
can be converted in the body to the harmful one   : (
(I helped save b3ta! finnbar has officially retired, Tue 29 Sep 2009, 19:50, archived)
# I didn't think this
could happen with optical isomerism.
(I helped save b3ta! monkeybananaraffle, Wed 30 Sep 2009, 17:22, archived)
# I'm afraid it can. I've been doing a little digging.
A similar thing happens with ibuprofen.
The non-active isomer gets converted (by an enzyme) to the active one (not the other way around, fortunately - otherwise it would be useless).

In the case of thalidomide, both isomers are active : one isomer suppresses morning sickness, the other causes birth defects.
Unfortunately, the beneficial isomer can be converted in your body to the harmful one, although I'm not sure if the conversion can go the other way.
(I helped save b3ta! finnbar has officially retired, Wed 30 Sep 2009, 23:20, archived)
# Science^2
Well, yes, but the two isomers can convert in-vivo, so although there is a safer form, I'd still not want to risk it.
(I helped save b3ta! Ungersven would support SpankyHanky's patreon, Fri 2 Oct 2009, 19:27, archived)
# THICKO!
*points and laughs*
(I helped save b3ta! Fitznicely into a thimble, Tue 29 Sep 2009, 19:00, archived)
# Jesus would point too
but he has to swing around to do it ;)
(I helped save b3ta! maiden is filmed before a live studio audience, Tue 29 Sep 2009, 19:03, archived)
# I had to filename.
w/y/h!
(I helped save b3ta! Crystal Magnet Like a diamond geezer, but better, Tue 29 Sep 2009, 19:03, archived)
# I didn't get it either...
..really thick of me as Thalidomide is in the news constantly huh ?
(I helped save b3ta! Grindstaff, Tue 29 Sep 2009, 22:20, archived)