Of course, caution is required. This isn't the end but it might be the end of the beginning, or something. It'll be at least a few months.
Still - this is a great day.
Here are the not-dumbed-down actual facts (thus far), instead of the BoJoSchpiel.

(, Mon 9 Nov 2020, 18:27, Reply)
"No problem" I thought - dry ice is readily available. The bloody stuff sublimates at -78.5!
(, Mon 9 Nov 2020, 19:22, Reply)
But this won’t be the vaccine that you and I get due to some rather problematic handling requirements:
From the BBC:
“There are also massive manufacturing and logistical challenges in immunising huge numbers of people, as the vaccine has to be kept in ultra-cold storage at below minus 80C.”
(, Mon 9 Nov 2020, 19:24, Reply)
See freezer farms.
I mean, sure, it's a logistics thing.
Not a showstopper though.
It's fine.
The major concerns are;
a) Are there side-effects?
Probably nothing much, and so far, no. There's no reason to think there will be - but eh, caution. c/f thalidomide.
It was a relatively small trial, over a very short time.
b) Does it work for a long time?
We don't know. It was tested over a week.
Other similar vaccines tend to provide immunity for months or years; some need a "booster". We won't know that until months/years have passed.
(, Mon 9 Nov 2020, 20:31, Reply)
But it puts the cost per dose way up. This will get rolled out to the NHS and frontline services. The general population is far more likely to receive one of the other vaccines that will be far easier to handle.
(, Mon 9 Nov 2020, 20:52, Reply)
The vaccine can be safely stored at -20C (in the realms of a normal freezer) for shortish periods of time, and needs to be defrosted before injection anyway.
The -80C cold chain will only be needed for the backbone of storage and delivery to hubs. A standard cold chain infrastructure will do for the spokes to vaccination points.
(, Mon 9 Nov 2020, 23:42, Reply)