![[challenge entry]](/images/board_posticon_c.gif "Challenge Entry: National Suicide Week"){kind=small}
M1285A Blinded, Randomized, Comparative Study of Racecadotril to Loperamide on Stopping of Acute Diarrhoea in Adults.
Hwang-Huei Wang, Ming-Jium Shieh, Taichung, Taiwan; Taipei, Taiwan
Background and Objective: Raceadotril (Hidrasec ™) is a novel anti-diarrhoeal agent that inhibits enkephalinase thus preventing endogenous enkephalin-degradation. Raceadotril displays anti-diarrhoeal activity via a purely secretary mechanism. The main objective of this study is to compare the efficacy (primary objective -duration of diarrhoea), safety and tolerability of Raceadotril versus Loperamide in the treatment of acute diarrhoea in adults.
Patients and Methods: This is a single-blind, two-centre, randomized, comparative, parallel group study. Sixty-two adult patients with acute diarrhoea of not more than five days' duration were recruited. The patients were randomized to receive either Raceadotril at 100mg tid p.o. or Loperamide 2.0mg bid p.o. The medications were continued until recovery
(defined as 12 hours with no stools or 2 consecutive normal stools) or for a maximum of 7 days.
Results: The mean duration of diarrhoea in the Raceadotril group (n=31) was 19.5 hours and 13 hours for the Loperamide group (n=31) based on ITT population (p=0.23). And 19 hours in the Raceadotril group (n=23) compared to Please help me... Is there anybody out there? My job is utter shite. I'm dying inside. I am a dead man. Does anyone out there care? 13 hours for the Loperamide group (n=25) based on PP analysis (p=0.37). The differences between the two groups in terms of the duration of abdominal pain (p=0.95, ITT and p=0.71, PP) abd abdominal distension (p=0.56, ITT and p=0.52, PP) were not significant. The rate of success in clinical response, defined as complete resolution of all signs and symptoms with no additional treatment required, were high in both groups, 87.1% (ITT) and 95.6% (PP) in the Raceadotril group and 87.1% (ITT) and 92% (PP) in the Loperamide group. there were 15 (24%) patients who experienced at least one adverse event during the study: 8 (25%) in the Raceadotril group and 7 (22%) in the Loperamide group. The most common adverse events were: constipation, bloody stools and itching. Although there was no significant difference between the two groups in terms of constipation, the occurence of constipation in the Raceadotril group (12.9%, 4/31) was less than half (29%, 9/31) that of the Loperamide group.
Conclusion: Both Raceadotril and Loperamide are as effective in resolving signs and symptoms and duration of diarrhoea in adults. Both treatments achieved high clinical success rates with similar safety profile while lower number of constipation in Raceadotril group was observed.
Kill me now. Please. I want to die.....
Hwang-Huei Wang, Ming-Jium Shieh, Taichung, Taiwan; Taipei, Taiwan
Background and Objective: Raceadotril (Hidrasec ™) is a novel anti-diarrhoeal agent that inhibits enkephalinase thus preventing endogenous enkephalin-degradation. Raceadotril displays anti-diarrhoeal activity via a purely secretary mechanism. The main objective of this study is to compare the efficacy (primary objective -duration of diarrhoea), safety and tolerability of Raceadotril versus Loperamide in the treatment of acute diarrhoea in adults.
Patients and Methods: This is a single-blind, two-centre, randomized, comparative, parallel group study. Sixty-two adult patients with acute diarrhoea of not more than five days' duration were recruited. The patients were randomized to receive either Raceadotril at 100mg tid p.o. or Loperamide 2.0mg bid p.o. The medications were continued until recovery
(defined as 12 hours with no stools or 2 consecutive normal stools) or for a maximum of 7 days.
Results: The mean duration of diarrhoea in the Raceadotril group (n=31) was 19.5 hours and 13 hours for the Loperamide group (n=31) based on ITT population (p=0.23). And 19 hours in the Raceadotril group (n=23) compared to Please help me... Is there anybody out there? My job is utter shite. I'm dying inside. I am a dead man. Does anyone out there care? 13 hours for the Loperamide group (n=25) based on PP analysis (p=0.37). The differences between the two groups in terms of the duration of abdominal pain (p=0.95, ITT and p=0.71, PP) abd abdominal distension (p=0.56, ITT and p=0.52, PP) were not significant. The rate of success in clinical response, defined as complete resolution of all signs and symptoms with no additional treatment required, were high in both groups, 87.1% (ITT) and 95.6% (PP) in the Raceadotril group and 87.1% (ITT) and 92% (PP) in the Loperamide group. there were 15 (24%) patients who experienced at least one adverse event during the study: 8 (25%) in the Raceadotril group and 7 (22%) in the Loperamide group. The most common adverse events were: constipation, bloody stools and itching. Although there was no significant difference between the two groups in terms of constipation, the occurence of constipation in the Raceadotril group (12.9%, 4/31) was less than half (29%, 9/31) that of the Loperamide group.
Conclusion: Both Raceadotril and Loperamide are as effective in resolving signs and symptoms and duration of diarrhoea in adults. Both treatments achieved high clinical success rates with similar safety profile while lower number of constipation in Raceadotril group was observed.
Kill me now. Please. I want to die.....
From the National Suicide Week challenge. See all 393 entries (closed)
(, Fri 12 Dec 2003, 22:02, archived)
Erm.You could have edited the original post.
(
King Ralph is drunk,
Fri 12 Dec 2003, 22:03,
archived)
I had rather hoped slight sarcasmwould put you off posting huge chunks of text.
(
Pootle,
Fri 12 Dec 2003, 22:19,
archived)
Plenty ofhelpful tips in this week's compo.
G'night All, have a great weekend everyone
(G'night All, have a great weekend everyone
Dogtanian,
Fri 12 Dec 2003, 22:04,
archived)
night nightbed bugs and all that
(
M3Essential and The Essentials. LIVE!,
Fri 12 Dec 2003, 22:05,
archived)
I'd probably want to die tooif I could be arsed to read all that...
(
Lethe is carrying a spade. SPANG.,
Fri 12 Dec 2003, 22:04,
archived)
I know...I have to type the likes of this for 8 1/2 hours a day. It is KILLING me.
(,
Fri 12 Dec 2003, 22:06,
archived)
I think you would be justified in addinga couple of lines bemoaning the crappness of your job, then, to see if anyone is actually reading this stuff and therefore nearly as bad off as you are... ^_^
( Lethe is carrying a spade. SPANG.,
Fri 12 Dec 2003, 22:07,
archived)
Arf!That's the way, just let it all out...
( Lethe is carrying a spade. SPANG.,
Fri 12 Dec 2003, 22:35,
archived)