I think you mean "What's wrong with them?"
"What's wrong with they?" is incorrect.
( Mr. Tea 'ulmmm'/'mmneurgh', Fri 16 Oct 2026, 23:05, Reply)

or the singular, "What wrong with him"

( mofaha ┐( ˘_˘)┌ ʅ(́◡◝)ʃ, Fri 16 Oct 2026, 23:29, Reply)

"it"

( 2 Can Chunder Word to your mums — I came to prod bums, Sat 17 Oct 2026, 0:00, Reply)

see also: "what all is wrong with all y'all"

( mofaha ┐( ˘_˘)┌ ʅ(́◡◝)ʃ, Sat 17 Oct 2026, 0:23, Reply)

Fuck y'all, all o y'all, if y'all don't like me, blow me

( mr horrible up yours, dickface, Sat 17 Oct 2026, 0:32, Reply)

'What's wrong with "they"?' = correct
'What's wrong with them?' = correct

HTH
( .Yeti., Sat 17 Oct 2026, 0:32, Reply)

Thanks dot yeti dot

( mr horrible up yours, dickface, Sat 17 Oct 2026, 0:33, Reply)